The 22nd International Conference on Diseases of Fish and Shellfish, the largest scientific event in the field of aquatic animal health, will take place at the Cultural Center of Heraklion, Crete, from 1-4 September 2025. The conference is organized by the European Association of Fish Pathologists (EAFP) with Dr. Pantelis Katharios (Institute of Marine Biology, Biotechnology and Aquaculture of the Hellenic Centre for Marine Research),as the local organizer. This prestigious biannual event is expected to host 700-800 scientists from around the world, featuring four plenary talks by distinguished speakers and 25 thematic sessions covering the latest advancements in fish and shellfish diseases. The conference will provide a unique opportunity for knowledge exchange, scientific collaboration, and the promotion of sustainable aquaculture practices.